What is intracytoplasmic sperm injection (ICSI)?
IVF treatment is an option for couples struggling with infertility. ICSI is an advanced fertility treatment for male infertility. This gives best success in the hands of expert IVF doctors and embryologists.
In human being formation of an embryo from a woman’s egg and a man’s sperm is a very complex phenomenon. The sperm of a man is a moving cell inside the body . It must reach to the egg at appropriate time to fertilise. The released egg from ovary can survive for only 24 hours. You may face difficulty in conceiving if
- Sperm quantity is too low – oligospermia
- Your partner doesn’t produce sperms – Azoospermia
- Defects in sperm movement – Asthenospermia
- Sperm cannot penetrate the egg due to a thick covering – thick zona
The head of the sperm must attach to the covering (zona) of the egg so that it can fertilise a woman’s egg, After attachment the sperm penetrates through the outer layer to the inside of the egg . Fertilisation takes place in the cytoplasm of the egg.
Sometimes the sperm cannot penetrate the outer layer, for a variety of reasons. The egg’s outer layer may be thick or hard to penetrate or the sperm may be unable to swim. You will need ICSI in these cases to fertilise the egg inside the laboratory. During ICSI, a single sperm will be injected directly into the cytoplasm the egg.
How ICSI is different from IVF Treatment?
IVF and ICSI are two ways to fertilise an egg in the laboratory. 50,000 or more swimming sperm will be placed next to the egg in a laboratory dish in traditional IVF treatment. Fertilisation occurs spontaneously when one of the sperm enters into the cytoplasm of the egg. In the ICSI process, a tiny needle, called a micropipette, injects a single sperm into the center of the egg. Fertilisation achieved through ICSI can be up to 80-90% whereas through IVF treatment it is around 50 -60 %. The fertilised egg (now called an embryo) grows in a laboratory for 2 to 5 days. Your IVF specialist may advise for ICSI over IVF treatment if your partner has male infertility.
When do you need ICSI treatment?
ICSI helps to overcome fertility problems, such as:
- If your male partner produces too few sperm to do artificial insemination (intrauterine insemination [IUI]) or IVF treatment.
- The sperm may not move in a normal fashion, hence cannot reach up to the egg in time.
- The sperm may have trouble attaching to the egg , Intra cytoplasmic sperm injection overcomes this.
- Your partner may have azoospermia ( Nil Sperms) due to a blockage in the male reproductive tract. Your IVF specialist will directly obtain sperms from Testes through a minor procedure like PESA or TESE. ICSI treatment is helpful if your partner has obstructive azoospermia.
- At times, traditional IVF treatment fails to create embryos in some patients. ICSI can achieve fertilisation in such patients regardless of the condition of the sperm.
- IVM treatment (In vitro maturation of eggs)
- Frozen self or donor eggs
Does ICSI work for all?
ICSI fertilises up to 80% of eggs. But certain issues may occur during or after the ICSI process:
- Damage to the eggs – Hence it is advisable to take help of an expert embryology department.
- Fertilisation Failure- This can happen due to any inherent problem in any one of the couple.
- The embryo may stop growing after fertilisation due to several reasons.
Once fertilisation takes place, a couple’s chance of achieving pregnancy is same for IVF treatment and ICSI. Chances of Pregnancy in humans is up to 30-40 % even with very good embryos. This is due to the low implantation capacity of human uterus.
Can ICSI Treatment affect a baby’s development?
If a woman gets pregnant naturally, there is a 1.5% to 3% chance that the baby will have a major birth defect. The chance of birth defects associated with ICSI is similar to IVF, but slightly higher than in natural conception.
Some of the problems that cause infertility may be genetic. For example, male children conceived with the use of ICSI may have the same infertility issues as their fathers. Couple should go through a counselling process at a standard ICSI center with the help of Infertility specialists and embryologists.
Infertility appears to be a shadow in the lives of those who cherish parenthood. IVF treatment is a special technique to achieve pregnancy in those couples who cannot give birth naturally. IVF treatment is one of the most popular techniques in India for achieving pregnancy through Assisted Reproductive Technique. Egg donor IVF is a fertility treatment option for those who can’t use their own eggs due to various reasons. The egg donation process involves retrieving eggs from a woman who has normally functioning ovaries. After egg retrieval, the eggs are fertilised in the in vitro fertilisation (IVF) lab using sperm from the receiving couple’s partner, or in certain situations with donor sperm. At Femelife Fertility gynaecologists, embryologists and fertility counsellors offer you complete fertility solution for infertility. The team at Femelife includes highly experienced consists of infertility specialist Dr. Nabaneeta Padhy with 20 years of experience. The personalised care give at Femelife is passionate and motivating. Hitech laboratory and customised protocols have achieved high success at Femelife Fertility and many couples have realised their dream of parenthood. Services available at Femelife include IVF, ICSI, IMSI, PGD, Donor egg programme, Surrogacy, Blastocyst Culture, Assisted hatching, Embryo Donation, Round the clock Fertility care, Expert Embryology and Andrology.