What are the causes of PCOS?

PCOS can be classified into a lifestyle disorder having a hereditary basis. You are among 30% of women worldwide if you are diagnosed to have PCOS. Although it is not a life threatening condition it makes you feel sick. Apart from menstrual problems you get worries of infertility.  Environmental factors like high-caloric diets and reduced exercise play a major role in the high occurrence of obesity in women with PCOS.

Is Waist hip ratio important in PCOS?

BMI is a more sensitive, at least an important supplementary test in PCOS. The diagnostic laboratory value of total androgen in PCOS is better indicator than total testosterone. It is therefore critical for PCOS patients with clinical signs of androgen excess to maintain a normal body weight. Waist Hip ratio is a better predictor of metabolic syndrome in women with PCOS compared to other predictors including BMI.  

Obesity Causes PCOS

Obesity is a common finding in PCOS and aggravates many of its reproductive and metabolic features. About 25% of asymptomatic women with regular menses have PCO morphology on ultrasound. Many of these women have elevated androgen or luteinizing hormone (LH) levels, but some have normal reproductive function. Insulin resistance is a common finding in PCOS and is substantially worsened by obesity. Fasting insulin levels are increased in PCOS. Women with this condition are expected to have a high prevalence of impaired glucose tolerance. The risk for developing glucose intolerance is increased with increasing body mass index (BMI) and obesity.

What are the problems with Obese PCOS women?

Reproductive disturbances are more common in obese women regardless of the diagnosis of PCOS. Obese women are more likely to have menstrual irregularity and anovulatory infertility than normal-weight women. Weight reduction can restore regular menstrual cycles in these women. In obesity increased androgen production has been reported in women with upper-body obesity.  In PCOS bioavailable androgen levels are increased especially with central obesity. Androgens play an important role in determination of body composition.

PCOS, considered one of the most common endocrine conditions in women of childbearing age, may be present in up to 20% of women of reproductive age. The majority of cases of PCOS are undiagnosed.Ri…

Source: Risk of Diabetes in PCOS

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